At present, the collection of Archaic to Late Roman sculptures from Thessaloniki and Macedonia in general is displayed in the central section of the museum. They illustrate the history of Thessaloniki from prehistoric times to Late Antiquity. These rooms display architectural members from an Ionic temple of the 6th century bc, sculptures of all periods from Macedonia, exhibits from the excavations in the palace complex built by Galerius in Thessaloniki city centre, a reconstruction of the facade of the Macedonian tomb in Ayia Paraskevi, Thessaloniki prefecture, with genuine architectural members, and finds (mainly gold artefacts) of the Archaic and Classical periods from the Sindos cemetery. In all these rooms, certain important exhibits have been singled out and further information about them is given to help visitors appreciate the importance of each exhibit and of the area and the period from which it comes.
Apart from its permanent displays, the Archaeological Museum also hosts major temporary and thematic exhibitions. In the Manolis Andronikos Room, for instance, there is an exhibition titled The Coins of Macedonia from the 6th Century to 148 bc, with examples of coins that were circulating in Macedonia in that period. A showcase in the lobby of the museum displays some finds from the excavation of the Neolithic settlement at Makriyalo in Pieria, accompanied by information about the progress of the excavation.
The new wing hosts two exhibitions: The Gold of Macedon and The Thessaloniki Area in Prehistory. The former includes finds from numerous excavations in Central Macedonia. Taking the history of gold as its central theme, it presents the culture of Macedonia from the 6th century bc to 148 bc, discussing the use of gold (jewellery, sartorial decoration, gilding of objects and vessels, coins), the technology of the manufacture of gold jewellery, and the techniques of gold mining. There are also numerous finds from the cemeteries of Macedonia (Sindos, Ayia Paraskevi, Nea Filadelfia, Makriyalo, Derveni, Liti, Serres, and Evropos), and their role in the burial customs is described.
The point of the Thessaloniki in Prehistory exhibition is to recreate a picture of the Thermaic littoral before the city of Thessaloniki was built. It presents the first excavations, which were carried out during the First World War by British and French troops, and finds from the most important prehistoric settlements in the area (Thermi, Vassilika, Stavroupoli, Oraiokastro, Assiros, Toumba, and Kastana) divided into three chronological groups (Neolithic and Early and Late Bronze Age).