The museum is housed in a two-storey building that was constructed in 1969 and renovated internally in 1999. It has prehistoric, Hellenistic, Roman, and Byzantine finds from the Florina area.
 

On the ground floor are the prehistoric finds, chiefly from the excavations carried out in 1997–8 at Armenohori, but also from other excavations.

More specifically, there are ceramic wares, objects for everyday use, materials for building houses, stone and bone tools, spindle whorls, and figurines.

One impressive exhibit consists in the jaws of a 200,000–500,000-year-old mammoth, which was found in the village of Sotiras. Also on the ground floor are grave stelae of the Roman period from Vevi (2^nd–3^rd cent. ad), Petres (2^nd cent. bc), Sitaria (3^rd cent. ad), Vythkouki, Kastoria prefecture (320 bc); statues from Vevi (a male torso of the Roman period) and Lakia (a statue of Artemis of the Roman period); and an exceptional mosaic floor from a house of the Roman period at Kato Klines.
 

On the first floor are displayed finds of the Hellenistic period from Petres and Agios Pandeleimon Hill, most notably a sundial, a statue of Artemis, agricultural implements, and a reconstruction of a house of the Hellenistic period with its masonry, fireplace, storerooms, and other features.

There are also exhibits of the Byzantine and post-Byzantine period from the Prespa area, chiefly the basilica of Agios Ahillios (capitals, chancel screen closure panels, chancel screen colonnettes), frescoes from various churches, parts of a wood-carved chancel screen from the hermitage of the Transfiguration (Metamorfossi), and an Vema door from the Church of Agios Athanassios in the community of Agios Germanos (16^th cent.).