Late Byzantine painting experienced one of its most fertile periods in Macedonia. Thessalonike, having quickly cast off the Latin yoke (1204-1224), assumed a leading role in the artistic process, replacing Constantinople to a degree.
Though the beginnings of the painting that developed in Macedonia lay in a new painting style of Constantinopolitan provenance, it soon displayed specific traits that qualified it as a "school", and was to directly influence Serbian painting. Painters from Thessalonike were to work in the employ of Serb princes.
The heyday of "Macedonian" painting lasted only for the last few decades of the 13th century. From about 1330 until the capture of Thessalonike by the Turks in 1430 no works of originality were created.